Akanda, Mushfiq H. and Rai, Rajeev and Slipper, Ian J. and Chowdhry, Babur Z. and Lamprou, Dimitrios and Getti, Giulia and Douroumis, Dennis (2015) Delivery of retinoic acid to LNCap human prostate cancer
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Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing.
OBJECTIVES The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process. METHODS Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence...
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